Tryptase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S268100, C546S348000

Reexamination Certificate

active

07060716

ABSTRACT:
Compounds of the formula (I), in which M is a central building block selected from the group below in which A1, A2, K1 and K2 are as defined in the description, are novel effective tryptase inhibitors.

REFERENCES:
patent: 6489327 (2002-12-01), Bär et al.
patent: WO 95/32945 (1995-12-01), None
patent: WO 96/09297 (1996-03-01), None
patent: WO 98/04537 (1998-02-01), None
patent: WO 99/12918 (1999-03-01), None
patent: WO 99/24395 (1999-05-01), None
patent: WO 99/24407 (1999-05-01), None
patent: WO 99/40073 (1999-08-01), None
patent: WO 99/40083 (1999-08-01), None
patent: WO 00/14097 (2000-03-01), None
patent: WO 01/10845 (2001-02-01), None
patent: WO 01/10848 (2001-02-01), None
patent: WO 01/19809 (2001-03-01), None
patent: WO 01/46128 (2001-06-01), None
patent: WO 01/46168 (2001-06-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
See Oh et al., Journal of Immunology, 1992-2000, 2002.
Sommerhoff, American Journal of Respiratory and Critical Care Medicine , 164: 552-558. 2001.
Krishna, et al., “Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma”,J. Allergy Clin. Immunol., Jun., 2001, pp. 1039-1045.
Rice, et al., “Dibasic Inhibitors of human mast cell tryptase. Part 2: Structure-Activity Relationships and Requirements for Potent Activity”, Bioorganic & Medicinal Chemistry Letters 10, pp. 2361-2366 (2000).

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