Tryptamine analogs with 5-HT1D selectivity

Details Tryptamine analogs with 5-HT1D selectivity Tryptamine analogs with 5-HT1D selectivity

1994-10-04

1996-03-05

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20904

Patent

active

054969573

ABSTRACT:
Described herein are tryptamine analogs that display high binding affinity and selectivity for the 5-HT1D.beta. receptor, of the formula: ##STR1## wherein R.sup.1 represents a chain selected from C.sub.8-11 alkyl, C.sub.7-10 alkoxy, C.sub.8-11 alkanoyl and C.sub.7-10 alkanoyloxy wherein said chain is optionally substituted by hydroxyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxy and wherein one of the intervening carbons of said chain is optionally replaced with a heteroatom selected from oxygen, nitrogen and sulfur;

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