Chemistry: analytical and immunological testing – Optical result – With fluorescence or luminescence
Reexamination Certificate
2005-10-18
2005-10-18
Ceperley, Mary E. (Department: 1641)
Chemistry: analytical and immunological testing
Optical result
With fluorescence or luminescence
C436S087000, C435S023000
Reexamination Certificate
active
06955921
ABSTRACT:
A compound of the formula (I)wherein R1is a protecting group for Nα, R2is a protecting group for NG, and R3is aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O—C single bond, which liberates R3—OH; a diagnostic device comprising same; a method for preparing the diagnostic device; and a method of using the diagnostic device to detect levels of urinary trypsin inhibitor in a biological sample; and a diagnostic kit for detecting levels of urinary trypsin inhibitor in a biological sample.
REFERENCES:
patent: 3552928 (1971-01-01), Fetter
patent: 3846247 (1974-11-01), Kronish et al.
patent: 3897214 (1975-07-01), Lange et al.
patent: 4046513 (1977-09-01), Johnston
patent: 4046514 (1977-09-01), Johston et al.
patent: 4551428 (1985-11-01), Berger et al.
patent: 4645842 (1987-02-01), Corey
patent: 4657855 (1987-04-01), Corey et al.
patent: 4704460 (1987-11-01), Corey
patent: 4717658 (1988-01-01), Michaels
patent: 4774340 (1988-09-01), Corey et al.
patent: 5750405 (1998-05-01), Albarella et al.
patent: 6583108 (2003-06-01), Tamburini et al.
patent: 1349623 (1974-04-01), None
patent: 1369139 (1974-10-01), None
patent: 11-75896 (1999-03-01), None
Aogaichi T & Plaut GWE, “Assay of the esterase activity of thrombin, plasmin and trypsin with a chromogenic substrate p-nitrobenzyl p-toluenesulfonyl-l-arginine”,Thrombos. Haemostas. (Stutg.) 37: 253-261 (1977).
Baustert JH et al., “Fluorometric continuous kinetic assay of α-chymotrypsin using new protease substrates possessing long-wave excitation and emission maxima”,Analytical Biochemistry171: 393-397 (1988).
Chem Sources-U.S.A.(Chemical Sources International, Inc., 1999) [Title Page].
Desnuelle P, “Trypsin”,The Enzymes, Second Edition, Chapter 6, pp.—119-132 (Academic Press, New York and London, 1960).
Goldbarg JA & Rutenburg AM., “The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases.”Cancer11: 283 (1958).
Gray CJ et al., 4-methylumbelliferyl esters as fluorogenic substrates for proteases.Enzyme Microb. Technol. 5: 137 (1983).
Higashi S et al., “Tissue Factor Potentiates the Factor VIIa-catalyzed Hydrolysis of an Ester Substrate”,J. Biol. Chem. 267(25): 17990-17996 (Sep. 5, 1992).
Inouye K et al., “Synthesis of TACK, a new chloromethyl ketone derivative of arginine.”,Bull. Chem Soc. Japan47(1): 202 (1974).
Jensen KA & Crossland I, “Studies of thioacids and their derivatives. VII. On 2-phenyl-4(5H)-thiazolone.”Acta Chem. Scand: 17: 144 (1963).
Kuwajima S et al., “Automated measurement of trypsin inhibitor in urine with a centrifugal analyzer: comparison with other acute phase reactants.”Clin. Biochem. 23: 167 (1990).
Leytus SP et al., “Rhodamine-based compoundsa s fluorogenic substrates for serine proteinases”,Biochem, J. 209: 299-307 (1983).
Piette AM et al., “Urinary trypsin inhibitory activity for the diagnosis of bacterial infection: a prospective study in 690 patients.”European J. Med. 1: 273 (1992).
Technical Data on Methods of Measuring Urinary Trypsin Inhibitor(UTI) (Sakamoto, Kyoto Daiichi Kagaku Co., Ltd., Feb. 25, 1997).
Corey Paul F.
Felman Steven W.
Pugia Michael J.
Rehm Gary E.
Bayer Corporation
Ceperley Mary E.
McDermott Will & Emery LLP
LandOfFree
Trypsin substrate and diagnostic device, and method of using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Trypsin substrate and diagnostic device, and method of using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trypsin substrate and diagnostic device, and method of using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3447310