Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-12-27
2009-12-29
Graser, Jennifer E (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S234100, C424S184100, C530S300000, C530S350000, C530S825000, C514S002600
Reexamination Certificate
active
07638130
ABSTRACT:
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus,Orientia tsutsugamushifor the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
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Stover et al. The 56-kilodalton major protein antigen ofRickettsia tsutsugamushi: molecular cloning and sequence analysis of the sta56 gene and precise identification of a strain-specific epitope; 1990. 58(7): 2076-2084.
Kim et al. High-level expression of a 56-kilodalton protein gene (bor56) ofRickettsia tsutsugamushiBoryong and its application to enzyme-linked immunosorbent assays. 1993. 31(3):598-605.
Ohashi et al. Purification and partial characterization of a type-specific antigen ofRickettsia tsutsugamushi. infect immuno 57(5): 1427-1431.
Ohashi et al. Cloning and sequencing of the gene (tsg56) encoding a type-specific antigen fromRickettsia tsutsugamushi. Gene. 1990. 91(1):119-120.
Ching Wei-Mei
Dasch Gregory A.
Kelly Daryl J.
Charilla Albert M.
Graser Jennifer E
Hemby, Jr. Joseph K
The United States of America as represented by the Secretary of
Yang Ning
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