Truncated PSPA lacking a functional cell membrane anchor region

Details Truncated PSPA lacking a functional cell membrane anchor region Truncated PSPA lacking a functional cell membrane anchor region

1994-03-17

1998-09-08

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241901, 4242001, 4242441, 530350, 530825, 4352523, A61K 3909, A61K 39385, C07K 14315, C12N 121

Patent

active

058041931

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

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