Truncated mammalian growth factor DNA sequence

Details Truncated mammalian growth factor DNA sequence Truncated mammalian growth factor DNA sequence

1994-01-25

1995-10-17

Allen, Marianne P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530399, C12N 1518

Patent

active

054592500

ABSTRACT:
A truncated mammalian growth factor, displaying homology to both basic and acidic fibroblast growth factor in a single polypeptide, is disclosed herein. The growth factor is substantially smaller (i.e. has fewer amino acid residues) than the full-length mammalian growth factor, has a higher affinity for fibroblast growth factor receptors than full-length K-FGF and basic fibroblast growth factor and increased mitogenic activity. Also disclosed herein are DNA sequences encoding the truncated growth factor, pharmaceutical formulations containing the truncated growth factor and methods to heal burns and wounds in a mammal by administering the pharmaceutical formulations.

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