Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-03-27
1997-10-14
Walsh, Stephen G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 8, 530350, 530397, 530399, A61K 3818, C07K 14475
Patent
active
056772785
ABSTRACT:
The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
REFERENCES:
Bowie et al. 1990. Science 247: 1306-1310.
Bellosta, P. et al., J. Cell Biol. (1993) 121(3):705-713.
Finch, P.W. et al., Science (1989) 2:752-755.
Ron, D. et al., J. Biol. Chem. (1993) 268(4):2984-2988.
Gospodarowicz Denis J.
Masiarz Frank R.
Blackburn Robert P.
Chiron Corporation
Green Grant D.
Kemmerer Elizabeth C.
Simboli Paul B.
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