Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1995-06-06
1999-01-26
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 691, 435697, 4353201, 4351723, 4352523, 435325, C07K 14475, C12N 121, C12N 510, C12N 1563
Patent
active
058637672
ABSTRACT:
The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
REFERENCES:
Finch et al., Science 2:752-755 (1989).
Ron et al. 1993. J. Biol. Chem. 268:2984-2988.
Bowie et al. 1990. Science 247:1306-1310.
Bellosta et al. 1993. J. Cell. Biol. 121: 705-713.
Gospodarowicz Denis J.
Masiarz Frank R.
Blackburn Robert P.
Chiron Corporation
Fitzgerald David L.
Guth Joseph H.
Kemmerer Elizabeth C.
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