Truncated human tissue plasminogen activator

Details Truncated human tissue plasminogen activator Truncated human tissue plasminogen activator

1990-03-02

1993-02-09

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 964, C12N 1558

Patent

active

051852594

ABSTRACT:
Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed. A truncated human tissue plasminogen activator consisting essentially of amino acids 69-527 is produced using recombinant DNA techniques.

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