Truncated human IL-1 cDNA sequences which encode biologically-ac

Details Truncated human IL-1 cDNA sequences which encode biologically-ac Truncated human IL-1 cDNA sequences which encode biologically-ac

1988-04-21

1991-03-19

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 536 27, C12P 2100, C12N 120, C12N 1500, C07H 2104

Patent

active

050010573

ABSTRACT:
The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.

REFERENCES:
patent: 4766069 (1988-08-01), Auron et al.
Pharmacia P-L Biochemicals 1984 Product Reference Guide, p. 26.
Auron et al.; Proc. Natl. Acad. Sci. U.S.A., 81:7907, (1984).
Roberts et al.; Proc. Natl. Acad. Sci. U.S.A., 76:760, (1979).

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