Truncated forms of the hepatocyte growth factor (HGF) receptor

Details Truncated forms of the hepatocyte growth factor (HGF) receptor Truncated forms of the hepatocyte growth factor (HGF) receptor

1992-05-07

1996-11-05

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

435193, 435194, C12N 910, C12N 912, A61K 3845

Patent

active

055715095

ABSTRACT:
A protein, which is useful as an antagonist of hepatocyte growth factor, is composed of two disulphide-linked chains of 50 kDa and 75 or 85 kDa respectively, the 5 kDa chain being the .alpha.-chain of the tyrosine kinase encoded by the MET protooncogene and the 75 or 85 kDa chain being a C-terminal truncated form of the .beta.-chain of the said tyrosine kinase.

REFERENCES:
Biological Abstracts.-Microfilms. Abstr. No. 115341, vol. 86, No. 11, 1988 Philadelphia, PA US P. R. Tempest et al.: "Structure of the met protein and and variation of met protein kinase activity among human tumor cell lines".
Biological Abstracts.-Microfilms. Abstra. No. 124441, vol. 90, No. 11 Philadelphia, PA US p. 87096; A Iyer et al.: "Structure, tissue tissue-specific expression, and transforming activity of the mouse met protooncogene." (1990).
Cell. vol. 59, 1989, Cambridge, NA US, pp. 335-348; B. Mosley et al.: "The Murine Interleukin-4 Receptor: Molecular Cloning and Characterization of Secreted and Membrane Bound Form".
Prat, M. et al., C-Terminal Truncated Forms of Met, the Hepatocyte Growth Factor Receptor, Molecular and Cellular Biology, vol. 11, No. 12, pp. 5954-5962, Dec. 1991.
Naldini, L. et al., The tyrosine Kinase Encoded by the MET Proto-Oncogene is Activated by Autophosphorylation, Molecular and Cellular Biology, vol. 11, No. 4, pp. 1793-1803, Apr. 1991.
Ponzetto, C. et al., c-met is amplifieled but not mutated in a cell line with an activated met tyrosine kinase, Oncogene, vol. 6, pp. 553-559, 1991.
Gandino, L. et al., Protein Kinase-c Activation Inhibits Tyrosine Phosphorylation of the c-met Protein, Oncogene, vol. 5, pp. 721-725, 1990.
Gonzatti-Haces, M. et al. PNAS 85:21-25 (1988).

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