Truncated DANCE, DANCE complex and method of using these

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07906616

ABSTRACT:
A method of screening for a medicine capable of regulating generation of elastic fibrous tissue; and various means that are requisite for the method. In particular, the invention includes a polypeptide obtained by cleaving DANCE and a polynucleotide coding for the polypeptide; a method of cleaving DANCE; an antibody against the polypeptide obtained by cleaving DANCE; a method of measuring the amount of DANCE cleavage and a kit therefore; a DANCE variant and its polynucleotide; various DANCE complexes and a method of preparing such; a method of screening for a substance capable of regulating DANCE or a DANCE-specific protease, and a substance obtained by such screening method; an agent for regulating generation of elastic fibrous tissue; and a kit with DANCE and a polynucleotide coding for the same.

REFERENCES:
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
Nakamura et al, Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. Jan. 10, 2002;415(6868):171-5.
Kowal et al, EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature. Circ Res. May 28, 1999;84(10):1166-76.
USPTO in house BLAST alignment SEQ ID No. 2 with AF137350 performed Aug. 18, 2008.
van der Flier et al, Function and interactions of integrins. Cell Tissue Res. Sep. 2001;305(3):285-98.
T. Nakamura et al., “DANCE, A Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-Injured Arteries”, J. Biol. Chem., vol. 274, No. 32, pp. 22476-22483, Aug. 6, 1999.
X. Liu et al., “Elastic Fiber Homeostasis Requires Lysyl Oxidase-Like 1 Protein”, Nature Genetics, vol. 36, No. 2, pp. 178-182, Feb. 2004.
B. Loeys et al., “Homozygosity for a Missense Mutation in Fibulin-5 (FBLN5) Results in a Severe Form of Cutis Laxa”, Human Molecular Genetics, vol. 11, No. 18, pp. 2113-2118, 2002.
D. Markova et al., “Genetic Heterogeneity of Cutis Laxa: A Heterozygous Tandem Duplication within the Fibulin-5 (FBLN5) Gene”, Am. J. Hum. Genet., vol. 72, pp. 998-1004, 2003.
European Partial Search Report dated Aug. 9, 2007 in conjunction with EP application No. 05720545.2-2401 which is a counterpart to the present application.
Sasaki, T. et al., “Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases”, Euro. J. Biochem., vol. 240, No. 2, pp. 427-434, 1996.
Hirai, M. et al., “Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo, The Journal of Cell Biology”, vol. 176, No. 7, pp. 1061-1071, 2007.
Nakamura, T., Molecular Cardiovascular Medicine, vol. 3., No. 5, pp. 547-554, 2002.
Kuang P. et al., “Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair”, Am. J. Physiol. Lung Cell Mol. Physiol., vol. 285, No. 5, pp. L1147-1152, 2003.
Tsuruga, E. et al., “Induction of fibulin-5 gene is regulated by tropoelastin gene, and correlated with tropoelastin accumulation in vitro”, The International Journal of Biochemistry & Cell Biology, vol. 36, No. 3, pp. 395-400, 2004.
Schiemann, W. P. et al., “Context-specific Effects of Fibulin-5 (DANCE/EVEC) on Cell Proliferation, Motility, and Invasion”, The Journal of Biological Chemistry, vol. 277, No. 30, pp. 27367-27377, 2002.
Midwood, K. S. And Schwarzbauer, J. E., “Elastic Fibers: Building Bridges Between Cells and Their Matrix”, Current Biology, vol. 12, No. 8, pp. R279-R281, 2002.
Yanagisawa, H. et al., “Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo”, Nature, vol. 415, pp. 168-171, 2002.
Nakamura, T. et al., “Fibulin-5/DANCE is essential for elastogenesis in vivo”, Nature, vol. 415, pp. 171-175, 2002.
G. Kostka, Apr. 2005, European Molecular Biology Laboratory, Accession No. AJ133490.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Truncated DANCE, DANCE complex and method of using these does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Truncated DANCE, DANCE complex and method of using these, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Truncated DANCE, DANCE complex and method of using these will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2675413

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.