Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1997-09-18
1999-11-30
Nashed, Nashaat
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
435232, 43525233, 4353201, 536 232, A61K 3851, C12N 988
Patent
active
059938072
ABSTRACT:
Truncated derivatives of aspartase having enhanced catalytic activity and/or enhanced clot dissolution properties relative to native aspartase from E. coli. The enzymes are isolated by site-directed mutagenesis of DNA encoding aspartase. L-aspartic acid is manufactured by contacting fumarate and ammonium ion in the presence of an aspartase derivative.
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Jayasekera Maithri M. K.
Saribas Abdullah S.
Viola Ronald E.
Nashed Nashaat
The University of Akron
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