Truncated aspartase enzyme derivatives and uses thereof

Details Truncated aspartase enzyme derivatives and uses thereof Truncated aspartase enzyme derivatives and uses thereof

1999-03-19

2000-10-17

Nashed, Nashaat T.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

43525233, 4353201, 536 231, 536 232, C12N 988, C07H 2104

Patent

active

061330132

ABSTRACT:
Truncated derivatives of aspartase having enhanced catalytic activity and/or enhanced clot dissolution properties relative to native aspartase from E. coli. The enzymes are isolated by site-directed mutagenesis of DNA encoding aspartase. L-aspartic acid is manufactured by contacting fumarate and ammonium ion in the presence of an aspartase derivative.

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