Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-10-06
2009-12-08
Romeo, David S (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S252300, C435S320100, C435S325000, C536S023500, C536S024100, C530S324000
Reexamination Certificate
active
07629146
ABSTRACT:
The invention relates to fragments of an amino acid sequence of mature, full length24kDa fibroblast growth factor-2or an analog thereof. The fragments have an activity that inhibits the migration of cultured cells as well as inhibiting angiogenesis, tumor growth, or any other processes that involve the migration of cells in vivo. This fragment does not stimulate the proliferation of cells which is in contrast to activity shown by the mature, full-length24kDa fibroblast growth factor-2. The present invention also relates to a DNA molecule encoding the fragment, an expression vector and a transformed host containing the DNA molecule, and a method of producing the protein by culturing the transformed host. Moreover, the present invention relates to a therapeutic composition the24kDa fibroblast growth factor fragment and a pharmaceutically acceptable carrier.
REFERENCES:
patent: 5418158 (1995-05-01), Larsen
Piotrowicz et al. Dual activities of 22-24 kDa basic fibroblast growth factor; inhibition of migration and stimulation of proliferation. J Cell Physiol. Feb. 1999;178(2):144-53.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds), Aug. 1994, Springer Verlag, pp. 433 and 492-495.
Florkiewicz, R. Z. and Sommer, A. 1989. Human basic fibroblast growth factor gene encodes four polypeptides: Three initiate translation from non-AUG codons. Proc. Natl. Acad. Sci. USA 86:3978-3981.
Foster T D
Romeo David S
Savori M. Reza
The Scripps Research Institute
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