Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific...
Reexamination Certificate
2006-12-14
2009-06-09
Stucker, Jeffrey (Department: 1649)
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
C424S198100, C530S300000, C530S350000, C514S866000
Reexamination Certificate
active
07544365
ABSTRACT:
A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.
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Chan Yin
Dosch Hans-Michael
Salter Michael
Tang Lan
Dutt Aditi
Jagtiani & Guttag
Stucker Jeffrey
The Hospital for Sick Children
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