TRPV1 antagonists

Details TRPV1 antagonists TRPV1 antagonists

2008-10-23

2011-12-27

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S357000

Reexamination Certificate

active

08084616

ABSTRACT:
The present invention relates to compounds of formula (I)wherein X, R1, R2, R3, R4, R5, m, and n are defined in the specification are TRPV1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

REFERENCES:
patent: WO-2005004866 (2005-01-01), None
patent: WO-2005009987 (2005-02-01), None
Patani et. al., “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, 96, pp. 3147-3176.
Caplus 2007:230718, “Cyclohexenylamine derivatives and as inhibitors of dipeptidyl peptidase-iv (DPP-IV) and their preparation, pharmaceutical compositions and use in the treatment of various diseases”, Pei et. al.
Hcaplus 2006:1042526, Discovery of ((4R, 5S)-5-Amino-4-(2,4,5-trifluorophenyl)cyclohex-2-eny1)-(3-(trifluormethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7 (8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes, Pei et. al., 2006.
Patani et. al., “Bioiososterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, 96, pp. 3147-3176.

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