Troponin T gene promoter and derivatives thereof

Details Troponin T gene promoter and derivatives thereof Troponin T gene promoter and derivatives thereof

1991-02-19

1993-11-30

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 241, 4353171, 435 691, 4353201, 935 22, 935 70, 935111, C12N 1500, C12N 500, C07H 2100

Patent

active

052664880

ABSTRACT:
The regulatory elements of the troponin T gene promoter are disclosed. These elements comprise, from downstream to upstream, an essential proximal promoter element, a skeletal muscle-specific regulatory element, a cardiac muscle-specific regulatory element, a nonessential positive striated muscle regulatory element, and a nonessential negative regulatory element. Individual ones of these elements may be combined with one another, or with regulatory elements from other promoters, to form additional new promoters with different functional characteristics.

REFERENCES:
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Cooper, T. A. and Ordahl, C. P., "A Single Cardiac Troponin T Gene Generates Embryonic and Adult Isoforms via Developmentally Regulated Alternate Splicing", J. Biol. Chem. 260, 11140 (1985).
Miwa, T. and Kedes, L., "Duplicated CArG Box Domains Have Positive and Mutually Dependent Regulatory Roles in Expression of the Human-Cardiac Actin Gene", Mol. and Cell. Biol. 7, 2803 (1987).
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