Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2007-08-21
2007-08-21
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S675000, C564S080000, C564S123000, C564S161000, C568S303000
Reexamination Certificate
active
10450836
ABSTRACT:
Tropolone derivatives represented by the formula (I), which have retinoid actions and are useful as active ingredients of medicaments [R1to R4represent hydrogen atom, an alkyl group, or an alkoxyl group; the ring represented by Ar represents an aryl ring or a heteroaryl ring; X represents a single bond, —N═N—, —CON(R5)—, —(C═C)nCON(R6)—, —N(R7)CON(R8)—, —SO2N(R9)—, —N(R10)— (R5to R9represent hydrogen atom or an alkyl group, n represents 1 to 3, R10represents hydrogen atom, an alkyl group, or an acyl group), an alkylene group, an aryldiyl group, or a heterocyclic diyl group; Y represents hydrogen atom, —OR11(R11represents hydrogen atom, an alkyl group, or an acyl group), —NHR12(R12represents hydrogen atom, an alkyl group, an acyl group, or amino group), or a halogen atom
REFERENCES:
patent: 3391133 (1968-07-01), Donaruma
patent: 3424841 (1969-01-01), Donaruma
patent: 5235076 (1993-08-01), Asato et al.
patent: 5990136 (1999-11-01), Barbachyn et al.
patent: 6093736 (2000-07-01), Barbachyn et al.
patent: 43-14705 (1943-06-01), None
patent: 46-2574 (1971-01-01), None
patent: 57-50934 (1982-03-01), None
patent: 61-22047 (1986-01-01), None
patent: 61-76440 (1986-04-01), None
patent: 61215341 (1986-09-01), None
patent: 92/21643 (1992-12-01), None
patent: 95/04036 (1995-02-01), None
patent: 98/07708 (1998-02-01), None
Vieillescazes et al., 1985, CAS: 103:37118.
Vieillescazes et al., Heterocycles, 1985), 23(4), 927-30.
Ebisawa et al., Chemical & Pharmaceutical Bulletin, 2001, 49(4): 501-503.
Yamato, 1987, CAS:106:66807.
Bagli et al., J. of Medicinal Chemistry, 1979, 22(10): 1186-1193.
Masayuki Ebisawa et al., “Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropone Ring with Benzoic Acid Moiety in Retinoid Structure”, Chem. Pharm. Bull., vol. 49, No. 4, pp. 501-503 (2001).
English Language Abstract of JP 57-50934.
English Language Abstract of JP 61-22047.
English Language Abstract of JP 61-76440.
Yamazaki, M. et al., “Studies on Tropolone Derivatives Having Monoamine Oxidase Inhibitory Activity,”Yakugaku Zasshi, vol. 108, No. 8, pp. 754-757, 1988.
Ang, K.H. et al., “A/C-Ring Colchicine Analogues: a Comparison of Molecular Conformations of the Minimized and Crystal Structures,”Aust. J. Chem., vol. 50, pp. 115-122, 1997.
Barnard, J.F. et al., “Small Molecule Probes of Glyoxalase I and Glyoxalase II,”Biochimica et1994.Biophysica Acta, vol. 1208, pp. 127-135.
Ferguson, L.R. et al., “Three Consistent Patterns of Response to Substituted Acridines in a Variety of Bacterial Tester Strains Used for Mutagenicity Testing,”Mutation Research, vol. 157, pp. 29-37, 1985.
Takahashi K. et al., “Synthesis of 5-(1,3-Dithiol-2-Ylidene)-3, 6-Cycloheptadiene-1, 2-Dione ( or 7,10-Dithiasesquifulvalene-3,4-Quinone).Derivatives,”Chem. Lett., pp. 1505-1508, 1977.
Tsunetsugu J. et al., “The Synthesis of 4- and 5-(α- and β-Naphthyl) Tropolones,”Bull. Chem. Soc. Jap., vol. 49, No. 3, pp. 831-832, 1976.
Kagechika, H. et al., “Retinobenzoic Acids. 1. Structure-Activity Relationships of Aromatic Amides with Retinoidal Activity,”J. Med. Chem., vol. 31, p. 2182, 1988.
Evans, R. M. et al., “The Steroid and Thyroid Hormone Receptor Superfamily,”Science, vol. 240, p. 889, 1988.
Hashimoto, Y., “Retinobenzoic Acids and Nuclear Retinoic Acid Receptors,”Cell Structure and Function, vol. 16, pp. 113-123, 1991.
Hashimoto, Y. et al., “Expression of Retinoic Acid Receptor Genes and the Ligand-Bind Selectivity of Retinoic Acid Receptors,”Biochemical and Biophysical Research Communications, vol. 166, pp. 1300-1307, 1990.
Anderson Rebecca
Greenblum & Bernstein P.L.C.
Research Foundation Itsuu Laboratory
LandOfFree
Tropolone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tropolone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tropolone derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3842737