Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2011-01-04
2011-01-04
Kolker, Daniel E (Department: 1649)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
C514S001100, C514S007600, C514S008600, C514S009400, C514S017700, C530S350000
Reexamination Certificate
active
07862826
ABSTRACT:
The present invention relates to a composition including an effective amount of at least one of an antimicrobial peptide and a substance having an antimicrobial peptide effect and an effective amount of a neurotrophin. The composition can also include an effective amount of at least one of a growth factor and a neuropeptide. The present invention also relates a method of treating an injury to a nervous system of an animal that includes the steps of identifying the injury to the nervous system and applying to the injury an effective amount of at least one of antimicrobial peptide and a substance having an antimicrobial peptide effect. The method can also include applying an effective amount of one or more trophic factors selected from the group consisting of a growth factor, a neurotrophin, and a neuropeptide to the injury.
REFERENCES:
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5130298 (1992-07-01), Cini et al.
patent: 5183805 (1993-02-01), Lee et al.
patent: 5210185 (1993-05-01), Della Valle et al.
patent: 5218093 (1993-06-01), Guo et al.
patent: 5410019 (1995-04-01), Coy et al.
patent: 5457034 (1995-10-01), Della Valle et al.
patent: 5470828 (1995-11-01), Ballard et al.
patent: 5639664 (1997-06-01), Iwane et al.
patent: 5650496 (1997-07-01), Brierley et al.
patent: 5792831 (1998-08-01), Maloy
patent: 5821056 (1998-10-01), Lee
patent: 5998376 (1999-12-01), Witten et al.
patent: 2002/0090369 (2002-07-01), Murphy et al.
patent: 2003/0083389 (2003-05-01), Kao et al.
patent: 2007/0207209 (2007-09-01), Murphy et al.
patent: 0209738 (2002-02-01), None
Sitaram, et al., Biochimica et Biophysica Acta, 1462:29-54, 1999.
McAnulty et al., Am J Transplantation, 2:712-718, 2002.
Kulagina et al., Sens Actuators B Chem, 121(1):150-157, 2007.
Kagawa et al., Seminars in Respiratory Infect., 18(3): 183-195, 2003.
Houle et al., Experimental Neurology, 182:247-260, 2003.
A & G Pharmaceutical innovative drug discovery and biotechnology, “PCDGF” (PC cell-derived growth factor), http://www.agrx.net/technologies/pcdgf.html, 3 pgs., printed from website Jan. 29, 2004.
Anderson, M. L. M. and Young, B.D., “Quantitative filter hybridization,” Chap. 4 of “Nucleic acid hybridization: a practical approach,” IRL Press Ltd, Oxford, England, pp. 73-110 (1985).
Baker-Herman, T. L. et al, “Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis,” J. Neuroscience, 22(14):6239-6246 (Jul. 15, 2002).
www.bbcm.units, ANTIMICROBIAL Peptides Laboratory, University of Trieste, Italy, http://www.bbcm.univ.trieste.it/˜antimic/Tossi—CV.html, 2 pgs., printed from website May 28, 2008 and Aug. 22, 2008.
Beaucage, S. L. et al, “Dexynucleoside phosphoramidites-a new class of key intermediates for deoxypolynucleotide synthesis,” Tetra. Letters, 22(20):1859-1862 (1981).
Biochem, “Growth Factor,” http://www.biochem.northwestern.edu/holmgren/Glossary/Definitions/Def-G/growth—fact..., 1 pg., printed from website Jan. 16, 2004.
Bramachary, M. et al, “ANTIMIC: a database of antimicrobial sequences,” Nucleic Acids Research, 34:D586-D589, 2004. (http://sdmc.lit.org.sg/Templar/DB/Antimic/).
Braverman, J. M., “Airway clearance needs in spinal cord injury: an overview,” 1999-2001 Advanced Respiratory, 6 pgs.
Carey, F. A. et al, “Advanced organic chemistry, Part B: Reactions and synthesis,” 5th ed., Springer Science, NY (2007), (book's Table of Contents, 10 pgs.).
Eisenhauer, P. B. et al, “Purification and antimicrobial properties of three defensins from rat neutrophils,” Infection and Immunity 57(7):2021-2027 (1989).
Fuller, D.D. et al, “Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury,” J. Neuroscience, 23(7):2993-3000 (Apr. 1, 2003).
Ganz, T. et al, “Defensins: natural peptide antibiotics of human neutrophils,” J. Clin. Invest. 76:1427-1435 (1985).
Garstang, S. V., “Cardiovascular concerns in spinal cord injury,” http://www.emedicine.com/pmr/topic20.htm, 13 pgs, printed from website Jan. 16, 2004.
Kamysz, W. et al, “Novel properties of antimicrobial peptides,” Acta Biochimica Polonica, 50:461-469, Feb. 2003.
Lehrer, R. I. et al, “Nonoxidative fungicidal mechanisms of mammalian granulocytes: demonstration of components with candidacidal activity in human, rabbit, and guinea pig leukocytes,” Infection and Immunity, 11(6):1226-1234 (1975).
Lehrer, R. I. et al, “Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes,” J. Virol. 54:467-472 (1985).
Lehrer, R. I. et al, “Fungicidal components of mammalian granulocytes active againstCryptococcus neoformans,” J. Infect. Disease, 136(1):96-99 (1977).
Merrifield, R. B., “Solid phase peptide synthesis. I. The synthesis of a tetrapeptide,” J. Am. Chem. Soc. 85:2149-2156 (1963).
Merrifield, R. B. et al, “Design and synthesis of antimicrobial peptides,” Ciba Found Symp. 186:5-26 (1994).
Mitchell, Gordon S. et al, “Physiological and genomic consequences of intermittent hypoxia invited review: intermittent hypoxia and respiratory plasticity,” J. Appl Physiol 90:2466-2475 (2001).
Murphy, C. J. et al, “Defensins are mitogenic for epithelial cells and fibroblasts,” J. Cell. Physiol. 155:408-413 (1993).
National Institute of Neurological Disorders and Stroke, “Spinal cord injury: hope through research,” http://www.ninds.nih.gov/health—and—medical/pubs/sci.htm, 26 pgs, printed from website Jan. 21, 2004.
National Institute of Neurological Disorders and Stroke, “Spinal cord injury: emerging concepts,” http://www.ninds.nih.gov/health—and—medical/pubs/sci—report.htm, 40 pgs, printed from website Jan. 21, 2004.
Neuromuscular, “Trophic factors,” 16 pgs., http://www.neuro.wustl.edu
euromuscular/lab/trophic.htm, printed from website Jan. 19, 2004.
Newton, C. R. et al, “PCR”, 2nd Ed., Springer-Verlag (New York, 1997), pp. 24-25.
Nih, Growth factor-Glossary Entry, “Genetics Home Reference,” http://ghr.nlm.nih.gov/ghr/glossary/growthfactor, 1 pg., printed from website Jan. 16, 2004.
Nscia, “About spinal cord injury,” 4 pgs., http://www.spinalcord.org/html/injury.php, printed from website Jan. 15, 2004.
Otsuka, H. et al, “PEGylated nanoparticles for biological and pharmaceutical applications,” Advanced Drug Delivery Reviews, 55:403-419 (2003).
PNS (Peripheral Nerve Society), front page of website, http://pns.ucsd.edu/, printed Jan. 21, 2004.
Rein, R. et al, eds., “Computer-assisted modeling of receptor-ligand interactions,” Proceedings of 33rd OHOLO Conference held in Eilat, Israel, Apr. 24-28, 1988, Alan R. Liss, Inc., NY (1989). Table of Contents.
Romeo, D., et al, “Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils,” J. Bio. Chem, 263(15):9573-9575 (1988).
SCOP (Structural Classification of Proteins), “Protein: placenta growth factor-1, PLGF-1 from human (Homo sapiens),” http://scop.berkeley.edu/data/scop.b.h.bi.b.b.d.html, 1 pg., printed from website, Jan. 26, 2004.
Segal et al, “In vitro effect of phagocyte cationic peptides onCoccidioides immitis,” J. Infectious Disease, 151 (5):890-894 (1985).
Selsted, M. E. et al, “Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes,” Infection and Immunity, 45(1):150-154 (1984).
Selsted, M. E. et al, “Activity of rabbit leukocyte peptides againstCandida albicans,” Infection and Immunity 49 (1):202-206 (1985).
Selsted, M. E. et al, “Purification, primary structure, and antimicrobial activities of a guinea p
Golder Francis J.
McAnulty Jonathan F.
Mitchell Gordon S.
Murphy Christopher J.
Kolker Daniel E
MacFarlane Stacey
Whyte Hirschboeck Dudek S.C.
Wisconsin Alumni Research Foundation
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