Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-15
2007-05-15
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S304000, C546S118000, C546S126000
Reexamination Certificate
active
11013634
ABSTRACT:
The present invention provides compounds of formula (I)wherein X, Y, R1, R2and R3are as defined hereinabove.The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.
REFERENCES:
patent: 6855724 (2005-02-01), Basford et al.
patent: 1 118 858 (2001-07-01), None
patent: WO 91/11172 (1991-08-01), None
patent: WO 94/02518 (1994-02-01), None
patent: WO 98/55148 (1998-12-01), None
patent: WO 00/39125 (2000-07-01), None
Cascieri, M., et al., “The Chemokine/Chemokine Receptor Family: Potential And Progress For Therapeutic Intervention,”Current Opin. Chem. Biol., 2000, 420-427, vol. 4, No. 4.
Connor, et al., “Vpr Is Required For Efficient Replication Of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes,”Virology, 1995, 935-944, vol. 206, No. 2.
Dimitrov, et al., “Microculture Assay For Isolation Of Human Immunodeficiency Virus Type 1 And For Titration Of Infected Peripheral blood Mononuclear Cells”, Journal of Clinical Microbiology, 1990, 734-737, vol. 28, No. 4.
Greene, T., et al.,Protective Groups In Organic Synthesis, Third Edition, 1999, 494-653, John Wiley and Sons.
March, J.,Advanced Organic Chemistry, Fourth Edition, 1992, 652, Wiley Interscience Publication, New York.
Basford Patricia Ann
Stephenson Peter Thomas
Taylor Stefan Colin John
Wood Anthony
Hutchinson Keith D.
Owens Amelia A.
Pfizer Inc.
Zielinski Bryan C.
LandOfFree
Tropane derivatives useful in therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tropane derivatives useful in therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tropane derivatives useful in therapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3770849