Tropane analogs and methods for inhibition of monoamine transpor

Details Tropane analogs and methods for inhibition of monoamine transpor Tropane analogs and methods for inhibition of monoamine transpor

1997-07-11

1999-09-07

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558431, 560118, 560128, 564188, 568306, 568327, 568374, 568380, 568634, 568808, 568820, 570129, 570183, C07C25500, C07C 6974, C07C23300, C07C 49105

Patent

active

059489332

ABSTRACT:
New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.

REFERENCES:
patent: 3813404 (1974-05-01), Clarke et al.
patent: 5276211 (1994-01-01), Narula et al.
patent: 5288872 (1994-02-01), Davies et al.
patent: 5310912 (1994-05-01), Neumeyer et al.
patent: 5374636 (1994-12-01), Moldt et al.
patent: 5736123 (1998-04-01), Carroll
patent: 5736556 (1998-04-01), Moldt et al.

Affiliated with

Also associated with

Rating

Tropane analogs and methods for inhibition of monoamine transpor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tropane analogs and methods for inhibition of monoamine transpor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tropane analogs and methods for inhibition of monoamine transpor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1805705