TRL1 as an antifungal target

Details TRL1 as an antifungal target TRL1 as an antifungal target

2007-07-10

2007-07-10

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

Reexamination Certificate

active

10537581

ABSTRACT:
The present invention relates to a novel antifungal target, tRNA ligase (TRL1), screening methods for TRL1 inhibitors and their use as antifungal compounds, pharmaceutical compositions containing them and their use in medicine, specifically in the treatment of an individual susceptible to or suffering from an anti-fungal infection. In particular the compounds find use in the treatment of topical or mucosal (e.g. thrush and vaginal candidiasis) fungal infections, e.g. caused by fungus of theCandidaspecies, and for systemic infections, e.g. caused by fungi ofCandidaandAspergillusspecies, such as but not limited toC. albicans, Aspergillus flavusorAspergillus fumigatus.

REFERENCES:
patent: WO 02/02784 (2002-01-01), None
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Spaltmann, F, et al., Computer-aided target selection-prioritizing targets for antifungal drug discovery, 1999, Drug Discovery Today, 4: pp. 17-26.
Westaway, SK., et al., Structure and Function of the Yeast tRNA Ligase Gene*, 1988, J. Biol. Chem., 263(7): pp. 3171-3176.
Baymiller, J., et al., Isolation and sequence of the t-RNA ligase-encoding gene ofCandida albicans, 1994, Gene (Amsterdam), 142: pp. 129-134.
Phizicky, EM., et al., Yeast tRNA Ligase Mutants Are Nonviable and Accumulate tRNA Splicing Intermediates*, 1992, J. Biol. Chem., 267(7): pp. 4577-4582.

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