Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-03-14
1993-07-27
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 74, 435 15, 435194, 436536, 530399, G01N 33567
Patent
active
052310019
ABSTRACT:
The present invention relates to a complex comprising nerve growth factor (NGF) and trk-proto-oncogene protein. The present invention also relates to methods for detecting the presence of NGF and trk-proto-oncogene receptor. The present invention further relates to methods that may be used in diagnostics and therapeutics for neurodegenerative diseases such as Alzheimer's and Huntington's by detecting NGF-trk receptor pairs.
REFERENCES:
Hempstead et al., "Expression of Functional Nerve Growth Factor Receptors After Gene Transfer", Science, vol. 243, Jan. 20, 1989, pp. 373-375.
Maher et al., "Nerve Growth Factor induces protein tyrosine phosphorylation", Proc. Nat'l Acad. Sci., USA, vol. 85, Sep. 1988, pp. 6788-6791.
Martin-Zanca et al., "Molecular and Bio Chemical Characterization of the Human TRK Proto-Oneogene", Mole & Cellar Bio, vol. 9, No. 1, Jan. 1989, pp. 24-33.
Lazarovici et al., "Long Terms, Heterologous Down Regulation of Epidermal Growth Factor Receptor in PC12 Cells lay Nerve Growth Factor", Journal Cell Biology vol. 104, 1987, pp. 1611-1621.
Taniuchi et al.,The Journal of Biological Chemistry 261(28):13342 (1986).
Kaplan, et al., Science 252:554 (1991).
Hempstead et al., Nature 350:678 (1991).
Ross et al., PNAS USA 81:6681 (1984).
Chandler et al., J. Biol. Chem. 259:6882 (1984).
Birren et al., Science 257:395 (1992).
Vetter et al., PNAS USA 88:8650 (1991).
Kaplan et al., Nature 6314:158 (1991).
Kaplan David
Martin-Zanca Dionisio
Parada Luis F.
Kepplinger Esther L.
The United States of America as represented by the Department of
Wortman Donna C.
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