Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
1998-09-22
Schain, Howard F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 721, G01N 33567
Patent
active
058113967
ABSTRACT:
The present invention relates to a complex comprising nerve growth factor (NGF) and trk-proto-oncogene protein. The present invention also relates to methods for detecting the presence of NGF and trk-proto-oncogene receptor. The present invention further relates to methods that can be used in diagnostics and therapeutics for neurodegenerative diseases such as Alzheimer's and Huntington's by detecting NGF-trk receptor pairs and the phosphorylation of trk protein.
REFERENCES:
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5231001 (1993-07-01), Kaplan et al.
Berg et al. J. Biol. Chem. 267(1): 13 (1992).
Hefti et al. "Neurotrophic Strategies in Neurodegenerative Disease", UCLA Symposium on Advances in Understanding Neurodegenerative Disorders, Jan. 1992.
Knusel et al. J. Neurochem. 57(3): 955 (1991).
Matthias et al. Neurosci. Lett. 121(1-2): 259 (1991).
Taoka et al. Biochem. Biophys. Res. Commun. 170(3): 1151 (1990).
Lagoo et al. Cell. Immunol. 127(2): 497 (1990).
Reymann et al. Brain Res. 461(2): 388 (1988).
Reymann et al. Exp. Brain Res. 71(1): 227 (1988).
Kase et al. Biochem. Biophys. Res. Commun. 142(2): 436 (1987).
Nakanishi et al. J. Antibiot. (Tokyo) 39(8): 1066 (1986).
Nagashima et al. FEBS. Lett. (Netherlands) 293(1-2): 119 (1991).
Doherty et al. Cell 67(1): 21 (1991).
Kaplan David R.
Parada Luis F.
Schain Howard F.
The United States of America as represented by the Department of
Touzeau P. Lynn
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