Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2005-12-27
2009-08-18
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
07576202
ABSTRACT:
The invention relates to a tritium-traced saxitoxin dihydrichloride of formula (I) whose radioactivity ranges from 15-31 Ci/mmol and to a novel method for introducing tritium into a molecule comprising stages required for introducing tritium label by isotope exchange associated with the obtainment of a stably-traced radioactive preparation which can be used, in particular for receptor binding analyses.
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“Synthesis of new highly radioactive tetrodotoxin derivatives and their binding properties to the sodium channel”; Robert Chicheportiche et al.; Eur. J. Biochem, 1980, 104, 617-625.
“Binding of [3H]batrachotoxinin A-20-α-benzoate and [3H]saxitoxin to receptor sites associated with sodium channels in trout brain synaptoneurosomes”; Jared R. Rubin et al.; Comporative Biochemistry and physiology, Part C: Pharmacology, toxicology & Endocrinology, 1993, 105C(2), 231-8.
International Preliminary Examination Report, with annexes and English translation of amended pages and conclusion of the IPER (13 pages).
International Search Report; PCT/RU2005/000672; Apr. 20, 2006.
Myasoedov Nikolay Fedorovich
Nagaev Igor Yulianovich
Shevchenko Valery Pavlovich
Susan Alexander
Fish & Richardson P.C.
Institut Molekulyarnoi Genetiki Rossiiskoi Akademh Nauk (IMG RAN
Leeser Erich A
Wilson James O
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