Tritium labelled N-mustard type compounds and a process for thei

Details Tritium labelled N-mustard type compounds and a process for thei Tritium labelled N-mustard type compounds and a process for thei

1984-10-18

1989-01-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

548954, 548962, 548966, 548968, 548969, 548336, 548468, 548546, 546275, 564355, 564384, 564389, 564503, A61K 4300, C07D20310, C07D20314, C07D20318

Patent

active

047956275

ABSTRACT:
The present invention describes novel tritium labelled nitrogen mustard type compounds, and their aziridinium type analog, and a process for the production of same. The compounds are of value in medical research and development and also as active ingredients of pharmaceutical compositions. The compounds can be used to develop analogs of human disease states and can also be used to evaluate the mechanism of neurotransmitter regulation and function, both in vitro and in vivo.

REFERENCES:
Bourgeois et al., Chem. Abstracts, vol. 77 (1972), Entry 149331f.
Li et al., Chem. Abstracts, vol. 95 (1981), Entry 128691e.
Madelmont et al., Chem. Abstracts, vol. 99 (1983), Entry 38011m.
Mantione et al., Science, vol. 213, (Jul. 1981) p. 579.
Evans, Tritium and its Compounds, 2nd ed., John Wiley & Sons (1974), pp. 106-113, 127-141 and 402-405.
Fisher et al., J. Pharm. and Exp. Therap., vol. 222(1), (1982) pp. 140-145.
Madelmont et al., J. Labeled Comp. and Radiopharm., vol. 20(1), (1982), pp. 7-17.

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