Tritiated .beta.-endorphin

Details Tritiated .beta.-endorphin Tritiated .beta.-endorphin

1978-11-13

1980-08-26

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

042194687

ABSTRACT:
Tritiated .beta.-endorphin is prepared by catalytic tritiation of a [3,5-diido-Tyr]-.beta.-endorphin which in turn is readily obtained by solid phase synthesis. The tritiated .beta.-endorphin preferably [3,5-diiodo-Tyr.sup.27 ]-.beta.-endorphin may be utilized as a radio-labelled tracer compound in radioimmunoassay for .beta.-endorphin and also exhibits biological activity comparable to that of the native .beta.-endorphin.

REFERENCES:
patent: 4038222 (1977-07-01), Li
patent: 4096237 (1977-06-01), Li
Lemaire et al., J. Am. Chem. Soc., 99, 1577-1580, (1977).
J. Ramachandras et al., Biochimica et Biophysica Acta., 496, (1977), 321-328.

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