Triterpene derivatives cholesterol acyltransferase inhibitors an

Details Triterpene derivatives cholesterol acyltransferase inhibitors an Triterpene derivatives cholesterol acyltransferase inhibitors an

1989-06-19

1991-01-22

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514559, 560173, 562508, C07C22900, C07C 6200, A61K 31215, A61K 3119

Patent

active

049871510

ABSTRACT:
The present invention provides a purified compound of the structure; ##STR1## wherein R may be palmitoyl or steroyl. The invention also provides compositions comprising an admixture of the foregoing palmitate and stearate esters.
The invention also provides a compound of the structure: ##STR2## The invention further provides pharmaceutical compositions including the aforementioned compounds and compositions and methods of inhibiting the acyl CoA: cholesterol acyltransferase catalyzed conversion of cholesterol to cholesteryl esters.

REFERENCES:
patent: 4448788 (1984-05-01), Toyoshima et al.
A. S. Katocs, et al., (1988), The Faseb Journal, 2:A1219 (Exhibit 2).
L. L. Gallo, et al., (1987), J. Lipid Res.; 28:381 (Exhibit 3).
B. Middleton et al., (1987), Drugs, 33 (Sup. 2): 75-79 (Exhibit 4).
J. L. Kelly et al., (1988), Biochimica Et Biophysica Acta, 960:83-90 (Exhibit 5).
E. E. Largis, et al., (1989), J. Lipid Res.; 30:681-690 (Exhibit 6).
S. B. Clark et al., (1984), J. Lipid Res.; 25:148-159 (Exhibit 7).
J. G. Heider et al., (1983), J. Lipid Res.; 24:1127-34 (Exhibit 8).
S. A. Schaffer, et al., (1986), Atherosclerosis VII; 633-636 (Exhibit 9).
I. Tabas et al., (1986), J. Biol. Chem.; 261:3147-3155 (Exhibit 10).
Nozakli et al. J. Chem Soc. Chem Commun. 1982 pp. 1048-1051.

Affiliated with

Also associated with

Rating

Triterpene derivatives cholesterol acyltransferase inhibitors an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triterpene derivatives cholesterol acyltransferase inhibitors an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triterpene derivatives cholesterol acyltransferase inhibitors an will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1555100