Triterpene derivatives and endothelin-receptor antagonists conta

Details Triterpene derivatives and endothelin-receptor antagonists conta Triterpene derivatives and endothelin-receptor antagonists conta

1995-07-26

1996-12-24

Conrad, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbonate esters

560 23, 560 51, 562 37, 562453, C07C 6996, C07C22934

Patent

active

055875050

ABSTRACT:
Triterpene derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or metabolic ester residue; and R.sup.2 is hydrogen or --R.sup.3 -R.sup.4 wherein R.sup.3 is --SO.sub.3 --, --CH.sub.2 COO--, --COCOO--, or --COR.sup.5 COO-- (R.sup.5 is lower alkylene or lower alkenylene), and R.sup.4 is hydrogen or metabolic ester residue or a pharmaceutically acceptable salt thereof, which have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.

REFERENCES:
Georgarakis, et al., Helv. Chim. Acta., 62(1), 234-70 1979.

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