Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from leguminosae
Reexamination Certificate
2011-07-26
2011-07-26
Flood, Michele (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from leguminosae
C536S018100, C514S025000, C514S033000
Reexamination Certificate
active
07985435
ABSTRACT:
The invention provides saponin mixtures and compounds which are isolated from the speciesAcacia victoriaeand methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
REFERENCES:
patent: 3070623 (1962-12-01), Gottfried et al.
patent: 3070624 (1962-12-01), Baxendale et al.
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4452901 (1984-06-01), Gordon et al.
patent: 4526714 (1985-07-01), Feijen et al.
patent: 4975369 (1990-12-01), Beavers et al.
patent: 5049388 (1991-09-01), Knight et al.
patent: 5183756 (1993-02-01), Schlom
patent: 5221605 (1993-06-01), Bard et al.
patent: 5238808 (1993-08-01), Bard et al.
patent: 5242813 (1993-09-01), Pastan et al.
patent: 5310687 (1994-05-01), Bard et al.
patent: 5607915 (1997-03-01), Patton
patent: 5919770 (1999-07-01), Hideo et al.
patent: 6444233 (2002-09-01), Arntzen et al.
patent: 6689398 (2004-02-01), Haridas et al.
patent: 6746696 (2004-06-01), Arntzen et al.
patent: 6962720 (2005-11-01), Haridas et al.
patent: 7105186 (2006-09-01), Arntzen et al.
patent: 2006/0073222 (2006-04-01), Arntzen et al.
patent: 753773 (1970-12-01), None
patent: 1346871 (1974-02-01), None
patent: 06073084 (1994-03-01), None
patent: HEI 07-165598 (1995-06-01), None
patent: WO 91/01750 (1991-02-01), None
patent: WO 96/02555 (1996-02-01), None
patent: WO 98/18810 (1998-05-01), None
patent: WO 98/37919 (1998-09-01), None
patent: WO 98/40100 (1998-09-01), None
patent: WO 98/52581 (1998-11-01), None
Agrawal, “NMR spectroscopy in the structural elucidation of oligosaccharides and glycosides,” Phytochemistry, 31:3307-3330, 1992.
Akiyama et al., “Genistein, a Specific Inhibitor of Tyrosine-specific Protein Kinases,”J. Biol. Chem., 262:5592-5595, 1987.
Alessi and Cohen, “Mechanism of activation and function of protein kinase B,”Curr. Opin. Gene. Dev., 8:55-62, 1998.
Anisimov et al., “Comparative study of cytotoxic activity of triterpene glycosides from marine organisms,”Toxicon., 18:221-223, 1980.
Anismov et al., “Mechanism of cytotoxic action of some triterpene glycosides,”Toxicon., 16:207-218, 1978.
Arnon et al., “Antiviral response elicited by a completely synthetic antigen with built-in adjuvanticity,”Proc. Natl. Acad. Sci. 77(11):6769-6772 1980.
Baxter et al., “Sapogenin structure: analysis of the13C- and1H-NMR spectra of soyasapogenol b,”J. Nat. Prod., 53:298-302, 1990.
Bellacosa et al., “Molecular alterations of theAKT2oncogene in ovarian and breast carcinomas,”Int. J. Cancer, 64:280-285, 1995.
Beraud et al., “Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation,”Proc. Natl. Acad. Sci. USA, 96:429-434, 1999.
Berton et al., “Epidermal proliferation but not the quantity of DNA photodamage is correlated with UV-induced mouse skin carcinogenesis,”Invest. Dermatol., 109:340-347, 1997.
Beutler et al., “Isolation and characterization of novel cytotoxic saponins form Archidendron ellipticum,”Bioorg. Med. Chem., 5(8):1509-1517, 1997.
Beutler, “Separation of high molecular weight saponins of archidendron ellipticum by hydrophilic interaction chromatography,”J. Liq. Chrom. &Rel. Technol., 20:2415-2426, 1997.
Bhandari et al., “A triterpene glycoside from Scrophularia koelzii,”Phytochemistry, 45:1717-1719, 1997.
Brinkmann et al., “B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice,”Proc. Natl. Acad. Sci. USA, 88(19):8616-8620, 1991.
Cantley and Neel, “New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway,”Proc. Natl. Acad. Sci. USA, 96:4240-4245, 1999.
Cha et al., “Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells,”Oncogene, 16:771-778, 1998.
Chatterjee et al., “Ultraviolet B radiation-induced DNA lesions in mouse epidermis,”Biochem. Biophys. Res. Commun., 229:590-595, 1996.
Cheatham et al., “Structural and functional analysis of pp70S6k,”Proc. Natl. Acad. Sci., 92:11696-11700, 1995.
Chen and Snyder, “Diosgenin-bearing, molluscicidal saponins fromAllium vineale: an NMR approach for the structural assignment of oligosaccharide units,”J. Org. Chem., 54:3679-3689, 1989.
Chen et al., “Structure determination of three saponins from the stem bark of Albizzia julibrissin Durazz,”Yaoxue Xuebao, 32(2):110-115, 1997.
Chen et al., “Studies on the triterpene sapogenins form Albizziae cortex,”Yaoxue Xuebao, 32(2):144-147, 1997.
Cho et al., “Agrobacterium rhizogenes-mediated transformation and regeneration of the legumeAstragalus sinicus(Chinese milk vetch),”Plant Science, 138:53-65, 1998.
Chou and Blenis, “The 70kDa S6 kinase complexes with and is activated by the Rho Family G proteins Cdc42 and Rac1,”Cell, 85:573-583, 1996.
Christey, “Transgenic crop plants usingAgrobacterium rhizogenes-mediated transformation,” Doran, P.M., (ed.)Hairy roots: Culture and applications, Harwood, Amsterdam, 99-111, 1997.
Davis et al., “Regulation of cholesterol synthesis and the potential for its pharmacologic manipulation,”Pharmac. Ther., 43:221-236, 1989.
DeNinno et al., “Steroidal glycoside cholesterol absorption inhibitors,”J. Med. Chem., 40:2547-2554, 1997.
Doll et al., “Clinical Trial of Triterpenoid Liquorice Compound in Gastric and Duodenal Ulcer,”Lancet, 1:793-796, 1962.
Downward, “Lipid-regulated kinases: some common themes at last,”Science, 279:673-674, 1998.
Enari et al., “Involvement of an ICE-like protease in Fas-mediated apoptosis,”Nature, 375:78-81, 1995.
Felley-Bosco, “Role of nitric oxide in genotoxicity: implication for carcinogenesis,”Cancer and Metastasis, 17:25-37, 1998.
Frank and Pahl, “Nutraceuticals-Food, dietary supplement or drug?”Biotech. Law Report, 18(2):131-143, 1999.
Frechet et al., “Four triterpenoid saponins from dried roots ofGypsophilaspecies,”Phytochemistry, 30:927-931, 1991.
Fujioka et al., “Antitumor Agents. 1681)Dysoxylum cumingianum., IV.2)The structures of Cumingianosides G-O, new triterpene glucosides with a 14,18-cycloapotirucallane-type skeleton fromDysoxylum cumingianum, and their ctytotoxicity against human cancer cell lines,”Chem. Pharm. Bull, 45(1):68-74, 1997.
Fulda, et al., “Betulinic Acid Triggers CD95 (APO-1/Fas)- and p53-independent Apoptosis via Activation of Caspases in Neuroectodermal Tumors,”Cancer Research, 57: 4946-4964, 1997.
Gariboldi et al., “Saponins fromCrossopteryx febrifuga,” Phytochemistry, 29(8):2629-2635, 1990.
Gorman, “How to tell the hype from the hope: a special report,”Cancer, 37-46, 1998.
Green and Reed, “Mitochondria and Apoptosis,”Science, 281:1309-1312.
Gura, “Cancer models: systems for identifying new drugs are often faulty,”Science, 278: 1041-1042, 1997.
Hamburger et al., “Acetylated saponins with molluscicidal activity fromSapindus rarak: unambiguous structure determination by proton nuclear magnetic resonance and quantitative analysis,”Phytochem. Anal., 3:231-237, 1992.
Haridas et al., “Avicins activate innate stress response by redux regulation of gene battery,” manuscript by Haridas et al., pp. 1-44, 2003.
Haridas et al., “Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by in
Arntzen Charles J.
Bailey David T.
Blake Mary E.
Gutterman Jordan U.
Hoffmann Joseph J.
Flood Michele
Fulbright & Jaworski LLP
Research Development Foundation
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