Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142285, 5142325, 544 582, 544 70, 544 81, 544118, 544256, A61K 31535, C07D48704

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active

056188145

ABSTRACT:
The invention relates to trisubstituted pyrimido [5,4-d]-pyrimidines of general formula ##STR1## (wherein R.sub.a, R.sub.b and R.sub.c are defined as in claim 1) and the salts thereof, more particularly for pharmaceutical use the physiologically acceptable salts thereof, which have, inter alia, valuable pharmacological properties, particularly in chemotherapy a sensitizing effect on resistant tumors, the use thereof and processes for preparing them.

REFERENCES:
patent: 4329346 (1981-05-01), Jardillier et al.
patent: 4478833 (1984-10-01), Roch et al.
N. Ramu andA. Ramu, Int'l J. Cancer, 43. pp. 487-491 (1989) "Circumvention of Adriamycin Resistance by Dipyridamole Analogues: A Structure Activity Relationship Study".

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