Trisubstituted amines, pharmacologically acceptable salts thereo

Details Trisubstituted amines, pharmacologically acceptable salts thereo Trisubstituted amines, pharmacologically acceptable salts thereo

1989-02-27

1991-03-12

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514338, 514343, 514422, 514428, 546256, 546281, 548517, 548527, 548526, 548569, 548570, 548573, 548574, 548575, A61K 3140, A61K 3144, C07D20706

Patent

active

049993615

ABSTRACT:
The present invention provides compounds of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom, a straight-chained or branched C.sub.1 -C.sub.12 -alkyl radical, a C.sub.3 -C.sub.7 -cycloalkyl radical, a straight-chained or branched C.sub.2 -C.sub.12 -alkenyl radical or an unsubstituted or substituted C.sub.3 -C.sub.7 -mono- or bicycloalkenyl radical, an unsubstituted or singly or multiple substituted monocyclic aromatic or heteroaromatic radical, R.sub.2 and R.sub.3, which can be the same or different, are straight-chained, branched, saturated or unsaturated C.sub.1 -C.sub.6 -aliphatic radicals or, together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring which can contain further heteroatoms and can optionally be substituted by a lower alkyl radical, a lower alkoxy radical or an oxygen atom, R.sub.4 is an unsubstituted or singly or multiple substituted monocyclic aromatic radical, an unsubstituted or substituted five- or six-membered heteroaromatic ring, R.sub.5 is a hydrogen atom, a cyano radical, a --CO--OR.sub.7 radical, an unsubstituted or a singly or multiple substituted monocyclic aromatic radical or an unsubstituted or substituted five- or six-membered ring, R.sub.6 is a hydrogen atom, a cyano group or a --CO--OR.sub.7, ##STR2## or --CH.sub.2 --O--R.sub.10 radical, R.sub.7 is a hydrogen atom, a C.sub.1 -C.sub.12 -alkyl radical or an N-dialkylamino-C.sub.1 -C.sub.6 -alkyl radical, R.sub.8 and R.sub.9, which can be the same or different, are hydrogen atoms or straight-chained, branched, saturated or unsaturated aliphatic C.sub.1 -C.sub.12 -aliphatic radicals or, together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring with 2 to 6 carbon atoms, R.sub.10 is a hydrogen atom, a straight-chained or branched C.sub.1 -C.sub.6 -alkyl or C.sub.2 -C.sub.6 -alkenyl radical, an aralkyl radical or an acyl radical, X is a valency bond or a methylene radical, Y is a valency bond or a straight-chained, branched, saturated or unsaturated hydrocarbon radical containing up to 6 carbon atoms and Z is a valency bond, or oxygen atom or a carbonyl group; as well as the pharmacologically acceptable salts and optical isomers thereof.
The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them for the treatment of heart and circulatory diseases.

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