Trisbenzimidazoles useful as topoisomerase I inhibitors

Details Trisbenzimidazoles useful as topoisomerase I inhibitors Trisbenzimidazoles useful as topoisomerase I inhibitors

1997-01-13

1999-09-07

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, A61K 3144

Patent

active

059487976

ABSTRACT:
The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub. 12)aryl or (6- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C.sub.1 -C.sub.4)alkyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, OCH.sub.3, NO.sub.2 or NH.sub.2 ; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; or a pharmaceutically acceptable salt therein.

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