Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-17
1998-09-15
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514253, 514256, 514394, 5462734, 5483054, 544238, 544333, 544405, A61K 3144, C07D40114
Patent
active
058078746
ABSTRACT:
The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl or (6- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C.sub.1 -C.sub.4)alkyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, OCH.sub.3, NO.sub.2 or NH.sub.2 ; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; or a pharmaceutically acceptable salt therein.
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LaVoie Edmond Joseph
Liu Leroy Fong
Sun Qun
Fan Jane
Rutgers The State University of New Jersey
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