Tris-maleimido compounds as intermediates in trifunctional antib

Details Tris-maleimido compounds as intermediates in trifunctional antib Tris-maleimido compounds as intermediates in trifunctional antib

1990-03-09

1992-02-25

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435 71, C07D207452, C12Q 100

Patent

active

050915428

ABSTRACT:
The present invention is directed to a compound for use as an intermediate in the production of novel trifunctional antibody-like compounds. More particularly, the present invention is directed to a compound of the formula: ##STR1## wherein X is ##STR2## wherein k=1 or 0;

REFERENCES:
patent: 4229351 (1988-10-01), Kiefer
patent: 4433059 (1984-02-01), Chang et al.
patent: 4659839 (1987-04-01), Nicoletti et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4722892 (1988-02-01), Meares et al.
patent: 4814438 (1989-03-01), Armour et al.
patent: 4837003 (1989-06-01), Nicoletti et al.
Glennie et al., "Preparation and Performance of Bispecific F(ab'.gamma.).sub.2 Antibody Containing . . . " J. Immunol., 139, 2367-75 (1987).
Masuho et al., "Cytotoxicity of a Hybrid Prepared by Coupling Diphtheria Toxin A-Chain with N,N'-o-phenylenedimaleimide", Biochem. and Biophys. Res. Comm. 102, 561-7 (1981).
Keller et al., "Preparation and Some Properties of Maleimido Acids and Maleoyl Derivatives of Peptides," Helvetica Chim. Acta, 58, 531-41 (1975).
Hashida et al., "More Useful Maleimide Compounds for the Conjugation of Fab' to Horseradish Peroxidase Through Thiol Groups in the Hinge", J. Appl. Biochem., 6, 56-63 (1984).
Hamaguchi et al., "Improved Procedure for the Conjugation of Rabbit IgG and Fab' Antibodies" . . . , J. Biochem., 85, 1289-1300 (1979).

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