Tris-Kringle plasminogen activator with novel K2 insert

Details Tris-Kringle plasminogen activator with novel K2 insert Tris-Kringle plasminogen activator with novel K2 insert

1987-12-31

1991-09-10

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435226, 4353201, 536 27, A61K 37547, C12N 964

Patent

active

050472410

ABSTRACT:
Tris-Kringle plasminogen activators containing an additional second kringle domain or an additional modified second kringle domain are useful in disrupting blood clots.

REFERENCES:
Harris, T. J. R., Protein Engineering, 1(6): 449-458, 1987.
Van Zonneveld et al, Proc. Natl. Acad. Sci, vol. 83, pp. 4670-4674, Autonomous Functions of Structural Domains on Human Tissue-Type Plasminogen Activator; Jul. 1986.
Vehar, G. et al, Biotechnology, pp. 1051-1057, Characterization Studies on Human Melanoma Cell Tissue Plasminogen Activator; Dec. 1984.
Patthy, Cell vol. 41, pp. 657-663, Evolution of the Proteases of Blood Coagulation and Fibrinolysis by Assembly from Modules; Jul. 1985.

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