Tris(isonitrile)copper(I) adducts for preparing radionuclide com

Details Tris(isonitrile)copper(I) adducts for preparing radionuclide com Tris(isonitrile)copper(I) adducts for preparing radionuclide com

1989-08-23

1991-04-16

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556 7, 556 13, 556110, 252 1, 558302, 534 14, 424 11, C07F 1300, C07F 108, C07C11902

Patent

active

050084186

ABSTRACT:
Tris(isonitrile)copper(I) complex salts with anions selected from BF.sub.4, PF.sub.6, ClO.sub.4, I, Br, Cl and CF.sub.3 COO are useful in preparing radionuclide complexes rapidly at room temperature. Preferred isonitrile ligands are ether isonitriles. The tris(isonitrile)copper(I) adducts enable technetium complexes, such as those of Tc99m, to be prepared easily just prior to their use as imaging agents.

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A New Tc-99m-Labeled Myocardial Imaging Agent, Hexakis (T-Butylisonitrile)-Technetium(1) [Tc-99mTB1]: Initial Experience in the Human, Holman et al.
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Evaluation in Dogs and Humans of Three Potential Technetium-99m Myocardial Perfusion Agents, Gerundini et al., J. Nucl. Med., 27(3), pp. 409-416 (1986).

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