Tris (hydroxymethyl) aminomethane salt of 2-mercaptosuccinic aci

Details Tris (hydroxymethyl) aminomethane salt of 2-mercaptosuccinic aci Tris (hydroxymethyl) aminomethane salt of 2-mercaptosuccinic aci

1979-04-25

1980-10-21

Breitenstein, G. T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 14, 435 17, 435188, C07C14920

Patent

active

042293693

ABSTRACT:
An improved reagent system for chemical determinations and novel compositions therefor provide improved reagent stability, particularly in a dry, storage stable phase. For determinations in which hexokinase and glucose-6-phosphate dehydrogenase are indicator enzymes, glycine and taurine are combined with bovine serum albumin to provide a bulking agent for the indicator enzymes which also acts as a stabilizer. A novel salt, the tris (hydroxymethyl)aminomethane salt of 2 mercaptosuccinic acid, acts as an activator or stabilizer in chemistries utilizing the indicator enzymes, namely determinations of creatine phosphokinase or glucose. The novel salt also acts as a stabilizer in a urea nitrogen determination. Dry reagent components are bulked in triethanolammonium terepthalate. Novel CPK, glucose and serum urea nitogen determinations are also provided.

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Anido et al., Quality Control in Clinical Chem., pp. 180-183, (Walter de Gruyter, Berlin 1975).

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