Tripterygium wilfordii Hook F extracts and components thereof fo

Details Tripterygium wilfordii Hook F extracts and components thereof fo Tripterygium wilfordii Hook F extracts and components thereof fo

1995-06-07

1999-06-29

Rollins, John W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514885, A61K 3578

Patent

active

059165642

ABSTRACT:
The present invention involves the use of Tripterygium Wilfordii Hook F extracts in the treatment of rheumatoid arthritis. An alcohol extract of this plant (T2) inhibited antigen- and mitogen-stimulated proliferation of T cells and B cells, cell cycle progression, interleukin-2 (IL-2) production by T cells, immunoglobulin production by B cells and interleukin-2 mRNA production. T2 did not affect IL-2 receptor expression by T cells, IL-1 production by monocytes, the capacity of monocytes to present antigen, or signaling pathways. Inhibition could not be accounted for by nonspecific toxicity. These results support the conclusion that T2 exerts a powerful suppressive effect on human immune responses. Suppressing autoimmune disease is a most preferred embodiment of this invention.

REFERENCES:
patent: 5294443 (1994-03-01), Lipsky et al.
International Search Report for related foreign application PCT/US96/15550, date of mailing Jan. 23, 1997.

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