Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1995-05-31
1997-04-01
Rollins, John W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 75, 435 79, 424 7805, 4241951, 514469, 514821, 514825, 514886, C12Q 100, G01N 3353, A61K 3174, A61K 3578
Patent
active
056164580
ABSTRACT:
The present invention provides for the use of Tripterygium wilfordii Hook F extracts and purified components thereof in the treatment of inflammation or an immune disorder with concomitant lack of steroidal effect. Extracts of this plant (T2) bound to the glucocorticoid receptor and competitively inhibited glucocorticoid mediated cellular processes, such as dexamethasone binding to the glucocorticoid receptor, glucocorticoid mediated activation of target genes, dexamethasone dependent cellular growth, with concomitant inhibition of cyclooxygenase-2 induction and inflammatory processes such as the production of prostaglandin E.sub.2. The T2 extract components triptolide and tripdiolide were effective inhibitors. The particular advantage provided by the methods herein is the treatment or prevention of inflammation and the concomitant lack of steroidal agonist effects and NSAID side effects. Conditions treatable by the present methods include inflammation and immune disorders including autoimmune disease.
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Cai Jian
Kovacs William J.
Lipsky Peter E.
Olsen Nancy J.
Tao Xue-Lian
Board of Regents, University of TX System
Mayfield Denise L.
Rollins John W.
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