Triplex and quadruplex catalytic hybridization

Details Triplex and quadruplex catalytic hybridization Triplex and quadruplex catalytic hybridization

2005-06-28

2005-06-28

Fredman, Jeffrey (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120

Reexamination Certificate

active

06911536

ABSTRACT:
An assay includes catalytic hybridization of targets and cleavable probes to form triplexes and quadruplexes based on Watson-Crick bonding rules. The probes contain scissile linkages that are cleaved by enzymes when hybridized to a target, yielding detectable probe fragments free of the target. The target is recycled to help catalyze the cleavage of additional intact probes to form additional detectable probe fragments, thus amplifying the signal.

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