Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-11-22
1999-02-23
Marschel, Ardin H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 436501, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, C07H 2104
Patent
active
058745556
ABSTRACT:
Oligonucleotides and processes for their use for specific recognition of a target sequence in double-stranded nucleic acid through the formation of a triple helix. The oligonucleotides can bind in a parallel or antiparallel orientation to one of the strands of the target sequence depending upon the sequence composition of the target sequence and oligonucleotide used. The oligonucleotides are used as diagnostic or therapeutic agents through incorporation of an appropriate moiety in one or more nucleotides in the triple helix forming oligonucleotide.
REFERENCES:
patent: 4358535 (1982-11-01), Falkon et al.
patent: 4563417 (1986-01-01), Albarella et al.
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4665184 (1987-05-01), Dervan et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4795700 (1989-01-01), Dervan et al.
patent: 4828979 (1989-05-01), Klevan et al.
patent: 4835263 (1989-05-01), Nguyen et al.
patent: 4837312 (1989-06-01), Dervan et al.
patent: 5422251 (1995-06-01), Fresco
Jiricny et al. (1986) Nucleic Acids Res., vol. 14, No. 16 pp. 6579-6590.
Eritja et al. (1986) Nucleic Acids Res., vol. 14, No. 20, pp. 8135-8153.
Le Doan et al. (1987) Nucleic Acids Res., vol. 15, No. 19, pp. 7749-7760.
Marck et al. (1978) Nucleic Acids Res., vol. 5, No. 3, pp. 1017-1028.
Strobel, S.A., et al., "Site-Specific Cleavage of Human Chromosome 4 Mediated by Triple-Helix Formation", Science 254:1639-1642, 1991 (Dec. 13).
Strobel, S.A., et al., "Single-side enzymatic cleavage of yeast genomic DNA mediated by triple helix formation", Nature 350:172-174, 1991 (Mar. 14).
Beal, P.A., et al., "Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation", Science 251:1360-1363. 1991(Mar. 15).
Horne, D.A., et al., "Effects of an abasic site on triple helix formation characterized by affinity cleaving", Nucleic Acids Research 19:4863-4965, 1991 (later than Aug. 9).
Griffin, L.C., et al., "Recognition of Thymine-Adenine Base Pairs by Guanine in a Pyrimidine Triple Helix Motif", Science 245:967-971, 1989.
Strobel, S.A., et al., "Double-Strand Cleavage of Genomic DNA at a Single Site by Triple-Helix Formation", J. Am. Chem. Soc. 110:7927-7929, 1988.
Luebke, K.H., et al., "Nonenzymatic Ligation of Oligodeoxyribonucleotides on a Duplex DNA Template by Triple-Helix Formation", J. Am. Chem. Soc. 111:8733-8735, 1989.
Strobel, S.A., et al., "Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA", J. Am. Chem. Soc. 111:7286-7287, 1989.
Povsic, T.J., et al., "Triple Helix Formation by Oligonucleotides on DNA Extended to the Physiological pH Range", J. Am. Chem. Soc. 111:3059-3061, 1989.
Strobel, S.A., et al., "Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation", Science 249:73-75, 1990.
Horne, D.A., et al., "Recognition of Mixed-Sequence Duplex DNA by Alternate-Strand Triple-Helix Formation", J. Am. Chem. Soc. 1990, 112:2435-2437, 1990.
Maher, L.J., III., et al., "Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation", Science 725-730, 1989.
Taylor, J.S., et al., "DNA Affinity Cleaving--Sequence Specific Cleavage of DNA by Distamycin-EDTA.multidot.Fe (II) and EDTA-Distamycin.multidot.Fe (II)", Tetrahedron 40:457-465, 1984.
Moser, H.E., et al., "Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation", Science 238:645-650, 1987.
Schultz, P.C., et al., "Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA.Fe (II)", PNAS 80:6834-6837, 1983.
Dreyer, G.B., et al., "Sequence-specific cleavage of single-stranded DNA:Oligodeoxynucleotide-EDTA.multidot.Fe (II)", PNAS 82:968-972, 1985.
Van Dyke, M.M., et al., "Echinomycin Binding Sites on DNA", Science 225:1122-1127, 1984.
Hertzberg, R.P., et al., "Cleavage of DNA with Methidiumpropyl-EDTA-Iron (II): Reaction Conditions and Product Analyses", Biochemistry 23:3934-3945, 1984.
Hertzberg, R.P., et al., "Cleavage of Double Helical DNA by (Medthidiumpropyl-EDTA) iron (II)", J. Am. Chem. Soc. 104:313-315, 1982.
Praseuth, D, et al., "Sequence-specific binding and photocrosslinking of .alpha. and .beta. oligodeoxynucleotides to the major groove of DNA via triple-helix formation", PNAS 85:1349-1353, 1988.
Francois, J-C., et al., "Sequence-targeted Cleavage of Single- and Double-stranded DNA by Oligothymidylates Covalently Linked to 1,10-Phenanthroline", J. Biol. Chem. 264:5991-5898, 1989.
Francois, J-C., et al., "Inhibition of Restriction Endonuclease Cleavage via Triple Helix Formation by Homopyrimidine Oligonucleotides", Biochemistry 28:9617-9619, 1989.
Sun, J-S., et al., "Sequence-specific intercalating agents: Intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates", PNAS 86:9198-9202, 1989.
Zerial, A., et al., "Selective inhibition of the cytophathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agent", Nucleic Acids Research 15:9909-9919, 1987. anti-messenger strategies", Nucleic Acids Research 15:10507-10521, 1987.
Durland, R.H., et al., "Binding of Triple Helix Forming Oligonucleotides to Sites in Gene Promoters", Biochemistry 30:9246-9255, 1991.
Cooney, M., et al., "Site-Specific Oligonucleotide Binding Represses Transcription of the Human c-myc Gene in Vitro", Science 241:456-459, 1988.
Williams, N.G., et al., "Dimers, Trimers, and Tetramers of Cytosine with Guanine", J. Am. Chem.Soc. 111:7205-7209, 1989.
Letai, A.G., et al., "Specificity in Formation of Triple-Stranded Nucleic Acid Helical Complexes: Studies with Agarose-Linked Polyribonucleotide Affinity Columns", Biochemistry 27:9108-9112, 1988.
Broitman, S.L., et al., "Formation of the triple-stranded polynucleotide helix, poly(A.multidot.A.multidot.U)", PNAS 84:5120-5124, 1987.
Lipsett, M.N., "Complex Formation between Polycytidylic Acid and Guanine Oligonucleotides", J. Biol. Chem. 2239:1256-1260, 1984.
Llyamchev, V.I., et al., "A stable complex between homopyrimidine oligomers and the homologous regions of duplex DNA", Nucleic Acids Research 16:2165-2176, 1988.
Rajagopal, P., et al., "Triple-strand formation in the homopurine:homopyrimidine DNA oligonucleotides d(G-A).sub.4 and d(T-C).sub.4 ", Nature 339:637-640, 1989.
Kohwi, Y., et al., "Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA", PNAS 85:3781-3785, 1988.
Hanvey, J.C., et al., "Site-specific inhibition of EcoRi restriction/modification enzymes by a DNA triple helix", Nucleic Acids Research 18:157-161, 1989.
Torrence, P.F., et al., "Triple-Helical Polynucleotides. Mixed Triplexes of the Poly(uridylic acid).multidot.Poly (adenylic acid) .multidot.Poly(uridylic acid) Class", Biochemistry 15:724-734, 1976.
Perlgut, L.E., et al., "Formation of triple-stranded bovine DNA in vitro", Nature 254:86-87, 1975.
Chu, B.C.F., et al., "Nonenzymatic sequence-specific cleavage of single-stranded DNA", PNAS 82:963-967, 1985.
Moffat, A.S., "Triplex DNA Finally Comes of Age", Science 252:1374-1375, 1991 (Jun.).
Dervan Peter B.
Moser Heinz E.
California Institute of Technology
Marschel Ardin H.
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