Triple helices and processes for making same

Details Triple helices and processes for making same Triple helices and processes for making same

1993-11-22

1999-02-23

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 436501, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 536 253, 935 77, 935 78, C07H 2104

Patent

active

058745556

ABSTRACT:
Oligonucleotides and processes for their use for specific recognition of a target sequence in double-stranded nucleic acid through the formation of a triple helix. The oligonucleotides can bind in a parallel or antiparallel orientation to one of the strands of the target sequence depending upon the sequence composition of the target sequence and oligonucleotide used. The oligonucleotides are used as diagnostic or therapeutic agents through incorporation of an appropriate moiety in one or more nucleotides in the triple helix forming oligonucleotide.

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