Triphosphate oligonucleotide modification reagents and uses...

Details Triphosphate oligonucleotide modification reagents and uses... Triphosphate oligonucleotide modification reagents and uses...

2011-08-16

2011-08-16

Lewis, Patrick (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S025330, C536S025340, C536S026100, C536S026800, C536S027100, C536S027130, C536S027200, C536S028100, C536S028400

Reexamination Certificate

active

07999098

ABSTRACT:
Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.

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