Triphenylphosphonium bromide intermediate for 2,2-fluoro-PG anal

Details Triphenylphosphonium bromide intermediate for 2,2-fluoro-PG anal Triphenylphosphonium bromide intermediate for 2,2-fluoro-PG anal

1976-09-17

1978-02-14

Myers, Jane S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07F 954

Patent

active

040738035

ABSTRACT:
2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

REFERENCES:
patent: 3531514 (1970-09-01), Redmore
patent: 3736349 (1973-05-01), Gillham et al.

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