Triphenylethylenes compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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Details

514648, 514720, 514739, A61K 31045, A61K 31075, A61K 31135

Patent

active

059122730

ABSTRACT:
A pharmaceutical composition is provided for use in the prevention or treatment of osteoporosis comprising a therapeutically effective amount of a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are independently H or OH, for the treatment or prevention of osteoporosis and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5605700 (1997-02-01), Degregorio
"Biochemical and Pharmacological Effects of Toremifene Metabolites", Cancer Chemotherapy and Pharmacology, Lauri Kangas, vol. 27, No. 1, pp. 8-12, 1990.
"Agnostic and Antagonistc Effects of Antiestrogens in Different Target Organs", Acta Oncologica, Lauri Kangas, vol. 31, No. 2, pp. 143-146, 1992.
"Phase I Clinical and Pharmacokinetics Study of High-Dose Toremifene in Postmenopausal Patients with Advanced Breast Cancer", Cancer Chemotherapy and Pharmacology, James Bishop et al., vol. 30, pp. 174-178, 1992.
"In Vitro and In Vivo Binding of Toremifene and Its Metabolites in Rat Uterus", The Jounral of Steroid Biochemistry, Niklas Simberg et al., vol. 36, No. 3, pp. 197-202, 1990.
"Effect of Anti-estrogens on Bone in Castrated and Intact Female Rats", Breast Cancer Research and Treatment, V. Craig Jordan et al., vol. 10, No. 1, 1987, pp. 31-35.
"Metabolism of Toremifene in the Rat", The Journal of Steroid Biochemistry, Hannu Sipila et al., vol. 36, No. 3, pp. 211-215, 1990.
"Pharmacokinetics of Toremifene", The Journal of Steroid Biochemistry, M. Anttila et al., vol. 36, No. 3, pp. 249-252, 1990.
"Anti-Oestrogens Induce the Secretion of Active Transforming Growth Factor Beta From Human Fetal Fibroblasts", Br. Journal Cancer, A.A. Colletta et al., vol. 62, pp. 405-409, (1990).

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