Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-06-02
1997-07-01
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514617, 514634, 514643, 514648, 560 34, 560 37, 564181, 564237, 564316, 564323, 564324, 564330, A61K 3114, C07C27906, C07C27908, C07C21103
Patent
active
056439504
ABSTRACT:
The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.
REFERENCES:
M. J. Mahan, J. M. Slauch and J. J. Mekalanos, Science, 259, 686-688 (1993).
S. Roychoudhury et al., Proc. Nat. Acad. Sci., 90, 965-969 (1993) Inhibitors of Two-Component Signal Transduction Systems: Inhibition of Alginate Gene Activation in Pseudomonas aeruginosa.
Demers James P.
Fraga Stephanie A.
Johnson Sigmond
Kanojia Ramesh M.
Klaubert Dieter
Ortho Pharmaceutical Corporation
Rotman Alan L.
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