Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-23
1999-02-23
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514277, 514317, 514331, 514357, 544398, 544399, 544400, 544401, 546236, 546232, 546239, 546334, 546335, 546337, 546342, C07D24104, C07D21120, C07D21182, C07D 31495
Patent
active
058744363
ABSTRACT:
The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.
REFERENCES:
patent: 5643950 (1997-07-01), Demers et al.
M. J. Mahan, J. M. Slauch and J. J. Mekalanos, Science, 259, 686-688 (1993).
S. Roychoudhury et al., Proc. Nat. Acad. Sci., 90, 965-969 (1993).
Inhibitors of Two-Component Signal Transduction Systems: Inhibition of Alginate Gene Activation in Pseudomonas Aeruginosa.
Demers James P.
Fraga Stephanie A.
Johnson Sigmond
Kanojia Ramesh M.
Klaubert Dieter
Dow Kenneth J.
Rotman Alan L.
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