Triphenylalkene derivatives

Details Triphenylalkene derivatives Triphenylalkene derivatives

1979-12-03

1986-11-18

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

26050118, 514428, 514648, 548575, 549419, 564324, A61K 31135, A61K 31205

Patent

active

046236600

ABSTRACT:
The disclosure relates to 1-p-aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phenylalk-1-ene derivatives, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-oestrogenic activity and are useful in the treatment of anovulatory infertility and the breast tumors. Representative of the compounds disclosed is 1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1-p-hydroxyphenyl-2-p-tolylbu t-1-ene.

REFERENCES:
patent: 3250767 (1966-05-01), Beneze
patent: 3493606 (1970-02-01), Richardson
patent: 3576874 (1971-04-01), Fried et al.
patent: 3721712 (1973-03-01), Palopoli et al.
Jordan et al., "Journal Endrcr.", vol. 75, pp. 305-316 (1977).

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