Tripeptidyl aminopeptidase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

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435 691, 4352523, 4352543, 4351723, 4353201, 536 232, C12N 962, C12N 1557, C12N 1511, C12N 1580

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058211047

ABSTRACT:
The present invention relates to a tripeptidyl aminopeptidase, a DNA construct encoding the tripeptidyl aminopeptidase, a method of producing tripeptidyl aminopeptidase and methods of reducing the tripeptidyl aminopeptidase production in cells in which tripeptidyl aminopeptidase activity is undesirable.

REFERENCES:
patent: 5616485 (1997-04-01), Hadary et al.
Butler, et al., Applied And Environmental Microbiology, vol. 61, No. 8, pp. 3145-3150 (1995).
Lees, et al., Chemical Abstract, vol. 113, No. 15, Abstract 128464 (Oct. 8, 1990).
Tsyperovych, et al., Ukrainian Biochemical Journal System of Aminopeptidases from Aspergillus flavus, vol. 49 No. 1, pp. 101-105, (1977).
Krieger, et al., FEBS Letters vol. 352, pp. 385-388 (1994).
Balow, et al., Biological Chemistry, vol. 258, No. 19, pp. 11622-11628 (Oct. 10, 1983).
McDermott et al., Biochemical Society Transactions, vol. 18, p. 667, (1990).
Watanabe, Y., et al., Biochemistry International, vol. 27, "Acidic tripeptidyl aminopeptidase in rat liver tritosomes: partial purification and determination of its primary substrate specificity", pp. 869-877, 1992 .

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